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By Y. Saturas. North Park University.

Dry skin has several causes: too much water contact purchase cheap furosemide on line, too much soap contact (switch to borax) furosemide 40mg without prescription, low body temperature quality furosemide 100 mg, not enough fat in the diet, or parasites. Grind the tablet first by putting it in a plastic bag and rolling over it with a glass jar. Cut a slit in the end to catch some cotton wool salvaged from a vi- tamin bottle and twist (cotton swabs, cotton balls and wooden toothpicks are contaminated with mercury, which in turn is polluted with thallium). Dip it into the glycerin mixture and ap- ply inside the nose with a rotating motion. Vitamin C powder (ascorbic acid); or 5 capsules, 1000 mg each Boil starch and water until clear, about one minute. Put a dab of the Quick Cornstarch Softener recipe on top of each wipe as you use it. Recipes For Natural Cosmetics Eye liner and Eyebrow Pencil Get a pure charcoal pencil (black only) at an art supply store. Try several on yourself (bring a small mirror) in the store to see what hardness suits you. To check this out for yourself, close your eye tightly and then dab lemon juice on your eyelid. Mix glycerin and water, half and half, and add it to the charcoal powder until you get the consistency you like. To make the lipstick stay on longer, apply 1 layer of lipstick, then dab some corn- starch over the lips, then apply another layer of lipstick. Store in a small glass or plastic container in the refrigerator, tightly covered in a plastic bag. Blush (face powder in a cake form) Add 50% glycerin to cornstarch in a saucer to make a paste. Try to make the consistency the same as your brand name product, and you can even put it back in your brand name container. Use white dis- tilled vinegar in your rinse water for a natural shine and ant repellent. Never use chlorine bleach if anybody in the home is ill or suffers from depression. Use grain alcohol (1 pint to 3 quarts water) for germ killing action instead of chlorine. Furniture Duster and Window Cleaner Mix equal parts white distilled vinegar and water. Since bo- ric acid is white, you must be careful not to mistake it for sugar accidentally. Start early in spring before they arrive, because it takes a few weeks to rid yourself of them once they are established. If you want immediate ac- tion, get some lemons, cut the yellow outer peel off and cover with grain alcohol in a tightly closed jar. To treat the whole house, pour vinegar all around your foundation, close to the wall, using one gallon for every five feet. Mix the following and scatter in trunks and bags containing furs and woolens: ½ lb. Carpet Cleaner Whether you rent a machine or have a cleaning service, don’t use the carpet shampoo they want to sell, even if they “guarantee” that it is all natural and safe. If you are just mak- ing one pass on your carpet, use the borax, alcohol, boric acid, and iodine. Health Improvement Recipes Black Walnut Hull Tincture This new recipe is four times as strong as the previous one, so it is called Black Walnut Hull Tincture Extra Strength. Your largest enamel or ceramic (not stainless steel, not aluminum) cooking pot, preferably at least 10 quarts Black walnuts, in the hull, each one still at least 50% green, enough to fill the pot to the top Grain alcohol, about 50% strength, enough to cover the walnuts Vitamin C powder, 1 tsp. The walnut is inside, but we will use the whole ball, uncracked, since the active ingredient is in the green outer hull. Pour into glass jars or bottles, discarding walnuts, and add more vitamin C (1 tsp. If the glass jar has a metal lid, put plastic wrap over the top before screwing on the lid. It is stronger than the concentrate made with just a few black walnuts in a quart jar (my earlier recipe), because there are more walnuts per unit liquid. In addition, you will not dilute it before use (although when you take it, it will usually be in water). If you are not going to use all of them in this batch, you may freeze them in a resealable plastic bag. To reduce air exposure, fill the pot as much as possi- ble, without touching the plastic wrap, while still keeping a snug fitting lid. Even more importantly, the glass jars or bottles you use to store your tincture should have as little air space as possible, without touching the plastic wrap on top. The idea is not to have partial jars, with a lot of air space, sitting for longer than a month or so. Remember, never use any kind of purchased water to make tincture or you will pollute it yourself. Black Walnut Hull Tincture (Regular Strength) This is the potency I used originally. The Extra Strength recipe is four times as potent as the original recipe, so it must be diluted in quarters. Black Walnut Hull Extract (Water Based) This recipe is intended for alcoholic persons: cover the green balls in the 10 quart (non-metal) pot with cold tap water. For use: in programs calling for Extra Strength Black Wal- nut Hull Tincture use four times as much of this water based recipe (8 tsp. Important Note: do not use bottled or purchased water to make this tincture or you could pollute it with isopropyl alco- hol! They can not be killed by zapping, because the high frequency current does not penetrate the bowel contents. Although most bowel bacteria are beneficial, the ones that are not, like Salmonellas, Shigellas, and Clostridiums are ex- tremely detrimental because they have the ability to invade the rest of your body and colonize a trauma site or tumorous organ. These same bacteria colonize a cancer tumor and prevent shrinking after the malignancy is stopped. One reason bowel bacteria are so hard to eradicate is that we are constantly reinfecting ourselves by keeping a reservoir on our hands and under our fingernails. You will know you succeeded when your tummy is flat, there is not a single gurgle, and your mood improves! Enemas If you should fail to have a bowel movement in a single day it is a serious matter. An ill person cannot afford to fill up fur- ther with the ammonia, the toxic amines, and toxic gasses that bowel bacteria produce. For many of us, the rectum and sigmoid colon have bal- looned out into a pocket due to past times of constipation. But in just a few weeks of daily cleansing, the pocket will shrink and may even disappear. Parasites and bad bacteria can escape being killed if they are in the diverticulum.

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They are easily treatable—frequent application of emollients and other precautionary measures (such as avoidance of harsh soaps discount 100 mg furosemide with amex, astringents buy furosemide overnight delivery, abrasives cheap furosemide 100mg visa, and excessive bathing) will ameliorate the situation. The mucocutaneous effects are dose depen- dent and reversible upon discontinuation of the retinoid. Teratogenicity, well documented as the most serious side effect of oral retinoids (32), is logically the potential concern with topical retinoids. With oral retinoids, most aromatic retinoids cross the placenta; in utero exposure results in limb and craniofacial deformities, as well as cardiovascular and central nervous system abnormalities. Systemic absorption of topical retinoids, however, is thought to be negligible (33). A large retrospective study of birth defects in off- spring born to mothers exposed to topical tretinoin (all-trans-retinoic acid) during pregnancy has demonstrated no significant risk (34). Even in light of this evidence, many clinicians feel strongly about avoiding topical retinoids in pregnancy (36). Reports of enhanced photocarcinogenicity in experimental mice exist (37), but no evidence exists of a comparable process with humans (38). Conversely, topical retinoids appear to have a protective effect against ultraviolet-induced premalignant and malignant lesions. However, skin treated with topical retinoids is more reactive to chemical and physical stresses (including ultraviolet light), because of the thinner horny layer and amplified vasculature. The successful trials of topical tretinoin have inspired the pursuit of other topical retinoids that could be effective in photoaging with fewer adverse effects. Undoubtedly, newer derivatives with safer adverse effect profiles will be forthcoming. Specifically, two new retinoids, adapalene and tazarotene, Topical Retinoids 119 licensed for the treatment of acne and psoriasis, respectively, will almost certainly be investigated for photodamage. Sus- tained improvement with prolonged topical tretinoin (retinoic acid) for photoaged skin. Topical treatment of multiple ac- tinic keratoses of the face with arotinoid methyl sulfone (Ro 14-9706) cream versus tretinoin cream: a double blind, comparative study. Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins character- istic of retinoic acid, but without measurable retinoic acid levels or irritation. Extraction of human epider- mis treated with retinol yields retro-retinoids in addition to free retinol and retinyl esters. In vitro metabolism by human skin and fibroblasts of retinol, retinal and retinoic acid. Molecular mechanisms of intrinsic skin aging and retinoid-induced repair and reversal. Among such diseases, malignant tumors should be diagnosed and treated properly be- cause some of them are quick to develop, destructive, or fatal. Hyperpigmentation of the face of middle-aged women, is most common; however, it is benign, and, if diagnosed and treated early, it can be prevented in the future. Melasma is commonly observed among middle-aged women (average age of 43) (1) and is rare in men. It is a diffuse or well-circumscribed noninflamma- tory brown hyperpigmentation that frequently occurs around the eyes, mouth, cheeks, and forehead. An experienced old Japanese dermatologist in Kyoto City often told melasma patients, ‘‘You need not treat melasma. Just live until the age of 70 and then the melasma you suffer from will disappear. Sato (1) measured various hormones by tritium (3H) radioimmunoassay in two groups of age-matched middle-aged women (av- erage age 43) with and without melasma on the seventh days of the ovarial and 123 124 Nakayama et al. Other hormones, such as estradiol, follicle stimulating hor- mone, luteinizing hormone, prolactin, androstendione, and cortisol (Fig. The increase in plasma progesterone may be attributed to the fact that melasma is exacerbated by pregnancy where plasma progesterone is increased or by contra- ceptive pills that occasionally contained progesterone; there is gradual decline of melasma after climacterium by 70 years of age. Histopathology of melasma shows an increase in melanin pigments in the epidermal cells especially in the supranuclear region of the basal cells (Fig. The number of epidermal melanocytes has not increased and, therefore, the hyper- pigmentation of melasma is considered to be functional and reversible. Two links, however, are still missing: the connection to the increase in serum progesterone Depigmentation Agents 125 Figure 1 Serum progesterone (P4) and estradiol (E2) levels of melasma patients and matched controls in follicular and luteal phases. Melasma has been regarded as an excellent target for newly developed depigmentation agents because many middle-aged melasma patients want to re- turn their skin color to normal. Long-term therapy is necessary so that depigmen- tation occurs slowly, without provoking severe depigmentation (as with hydro- quinone monobenzyl ether) or severe hyperpigmentation of ochronosis (as with hydroquinone at 2 4% concentrations under a tropical climate) (3). Histori- cally, both disorders had been reported (4) and, therefore, both are disastrous pitfalls for those developing depigmentation agents. First, unlike hydroquinone monobenzyl ether, the depigmentation agents under development should not kill melanocytes. Second, hydroquinone itself is not cytotoxic to melanocytes; however, it degenerates dermal elastic fibers under strong sunlight at high concentrations of 2–4%, which results in another disas- trous strong brown hyperpigmentation called ochronosis (5). Therefore, the best depigmentation agent inhibit tyrosinase in melanocytes, and toxicity to epidermal cells, melanocytes, dermis, and other systemic organs is negligible. Also, depig- mentation agents should not be strong sensitizers, oncogenic, or teratogenic. Hydroquinone cream changes color from white to brown after 3–4 months; therefore, it can be produced at pharmacies and hospitals on the condition that it is disposed of after the color changes. Hydroquinone cream is an excellent preparation for the treat- ment of melasma with or without mild chemical peeling (6,7). However, the color change and the production of ochronosis have inhibited its usage in cosmetics and cosmeceuticals. Mushroom tyrosinase has been commonly used, and the suppres- sion of tyrosinase could be demonstrated when dose-dependent inhibition was demonstrated with hydroquinone as an effective control. Another kind of tyrosi- nase assay is noninhibitory or nonsuppressive-type reactions of melanogenesis. According to Mishima (8), melanogenesis can also be hindered by tyrosinase production inhibition, inhibition of tyrosinase transfer, and cytotoxic inhibition (Table 3). Cultured B-16 melanoma cells have been used in this field and are useful in demonstrating several new mechanisms of melanogenesis inhibition: glycosylation turned out to be another process of the production, along with matu- 130 Nakayama et al. Suppression of tyrosinase Kojic acid Hydroquinone Ascorbic acid Arbutin Ellagic acid 2. Its inhibition also decreased the amount of melanin, and depigmentation agents were also found. Tyrosinase activities in ribosomes and the production of premelanosomes can also be targets for melanin production inhibition (8). There are two melanins, eumelanin (black brown) and pheome- lanin (yellow or red), and eumelanin production inhibition is usually considered with depigmentation agents. Dose-dependent reactions are requested for depigmenting agents in in vitro tests, like tyrosinase inhibition or B-16 melanoma cell assay. This is needed be- cause melanogenesis inhibition increases in parallel with the concentration of the depigmentation agents in the medium.

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